Physiologic assessment of blood glucose homeostasis via. When taken together with serum biochemical profiles, inclusive of blood glucose levels. Pdf analysis of intravenous glucose tolerance test data. Jan 09, 2020 the glucose tolerance test gtt is the most sensitive test for detecting borderline diabetes mellitus. Since the introduction of micromethods for the estimation of the bloodsugar the oral glucose tolerance test has been the accepted means of differentiating. The minimal model, which is the model currently mostly used in physiological research on the metabolism of glucose, was proposed in the early eighties for the interpretation of the glucose and insulin plasma concentrations following the intravenous glucose tolerance test. The intravenous glucose tolerance test gtt aids in evaluating the time to onset of diabetes among persons expressing antiislet autoantibodies. The intravenous glucose tolerance test ivgtt plays a key role in the characterization of glucose homeostasis. The simplified test used two cephalic catheters, implanted in unsedated, unanaesthetised cats three hours before the test. Application of the intravenous glucose tolerance test and the. No rebound phenomenon is noted by 120 minutes after injection. Positive association between a single abnormal glucose tolerance test value in pregnancy and subsequent abnormal glucose tolerance. In 20 healthy volunteers aged between 18 and 51 years.
Blood pyruvate and lactate levels during oral and intravenous glucose tolerance tests are described in obese and nonobese nondiabetic, maturityonset diabetic and insulinrequiring diabetic groups of women. Get a printable copy pdf file of the complete article 1. A simple intravenous glucose tolerance test for assessment. The intravenous glucose tolerance test ivgtt is used for very accurate assessment of the first phase of insulin release. Pdf the aim of the study was to find a simple intravenous glucose tolerance test ivgtt that can be used to estimate insulin sensitivity.
Using recently available pregnancy criteria a direct comparison of both the intravenous gtt and the oral gtts was undertaken in 149 pregnant women. Research design and methods we performed a frequently sampled intravenous glucose tolerance test fsigt with minimal model analysis and a meal tolerance test mtt in 20 subjects with impaired fasting glucose 11 men, 9 women. A simplified intravenous glucose tolerance test has been developed for use in domestic cats and the results compared with those obtained using the standard test. Intravenous glucose tolerance test in the pig 107 derived in 1 andis designated as tin this paper. The purpose of this study was to determine the normal range and test variability for intravenous glu cose tolerance test ivgtt in rabbits. Thepresentstudy describes the results obtained with a standard in travenous glucose tolerance test. The prevalence of type 2 diabetes in american adolescents has increased markedly during the past generation.
Mathematical modelling of the intravenous glucose tolerance test. A simple intravenous glucose tolerance test for assessment of insulin sensitivity robert g hahn1,2, stefan ljunggren2,3, filip larsen4 and thomas nystrom3 correspondence. Research paper response to intravenous glucosetolerance test and risk of cancer. Blood samples were collected before and after intravenous administration of glucose 0.
To analyze the data from these tests, new criteria were established to determine which glucose values to include in calculating the rate of disappearance of glucose, the k rate. Characterization of metabolic status in nonhuman primates. Isosteviol reduces plasma glucose levels in the intravenous. Intravenous glucose tolerance test by plotting the data log increment against time and then applying the formula k loge2 t where t is the time in minutes required for the blood glucose increment value at. There were 101 subjects with normal glucose tolerance ngt, 36 with impaired glucose tolerance igt, and 17 with type ii diabetes. An oral glucose tolerance test ogtt was performed on. Research open access a simple intravenous glucose tolerance. In suspects, intravenous testing gave a higher yield 16 per cent than oral testing 8 per cent. S1 and sg were measured by insulinmodified, frequently sampled intravenous glucose tolerance test fsigt. Glucose is carried to its metabolic sites directly by plasma water and only indirectly by red blood cells. Bilateral polyethylene iv cannulas were inserted into ante cubital veins.
Corrado f, danna r, cannata ml, cannizzaro d, caputo. The range and distribution ofglucose tolerance in a sample of 60 sows andgilts. Valdes 1 departments of obstetrics and gynecology and medicine. Several attempts at building a satisfactory model of the glucoseinsulin system are recorded in the literature. An intravenous glucose tolerance test automatically eliminates variations duetogastrointestinal factors. Full text full text is available as a scanned copy of the original print version. It was considered that the site fromwhichthe blood waswithdrawn might affect the results of the intravenous glucose tolerance. Thevariation in the deter minationoftandhalflife wasthencalculated. Zdf rats were divided into a control and three isosteviol treatment 1, 5 and 10 mgkg groups. In order to evaluate the diagnostic reliability of the oral glucose tolerance test ogtt and the intravenous glucose tolerance test ivgtt, the results of these two teats have beencompared. Blood pyruvate and lactate levels during oral and intravenous glucose tolerance tests are described in obese and nonobese nondiabetic, maturityonset diabetic and insulinrequiring diabetic groups of. Blood samples were collected from the ephalic vein of the opposite forelimb 10 min before infusion min. Abstract background the aim of the study was to find a simple intravenous glucose tolerance test ivgtt that can be used to estimate insulin sensitivity. Intravenous glucose tolerance test and glucose kinetic parameters in rabbits.
It is indicated by the nature of blood glucose curve following the administration of glucose. Nonpregnantoral criteria gave the lowest yield in suspects 7 per cent and a number of nondiagnostic responses 30 per cent which did not parallel. Oral and intravenous glucose tolerance tests were performed during the same week in the third trimester of pregnancy in each of 200 selected patients. Pdf intravenous glucose tolerance test and glucose. The intravenous glucose tolerance test in pregnancy1 by donald g. A computerized method of calculating the results of the intravenous glucose tolerance test ivgtt is presented. A frequently sampled intravenous glucose tolerance test 9 with minimal model analysis 10 was performed to assess insulin sensitivity. Background the unmodified frequently sampled intravenous glucose tolerance test fsigt has not previously been used to assess insulinglucose kinetics in patients with insulinoma objective to. The aim of this study was to test the effect of isosteviol on blood glucose and insulin levels during the intravenous glucose tolerance test ivgtt in wistar and zucker diabetic fatty zdf rats. Modeling studies of the insulin glucose relationship have mainly utilized parametric models, most notably the minimal model mm of glucose disappearance. The oral gtt suffers from the disadvantage that the changes in the blood glucose during the test depend to a large extent on the magnitude of the amount absorbed and the rate of intestinal absorption of glucose. If a series ofcurves is to be performed on the same subject. This is necessary because glucose clearance half times t 12 and urinary.
Thus glucose tolerance test is a valuable diagnostic aid in. Glucose tolerance test an overview sciencedirect topics. Glucose tolerance tests gtt have bee nextensively used for the study of carbohydrate metabolism in both experimental and clinical work. This article presents results from the comparative analysis of the parametric mm and a. The high dose intravenous glucose tolerance test and concurrent immunoreactive serum insulin and glucagon levels were measured and the results related to the presence or absence of pancreatic. Thepatienthasnofoodfor eighthourspriorto thetest, butmaybeallowed water to drink. The glucose tolerance test is a medical test in which glucose is given and blood samples taken afterward to determine how quickly it is cleared from the blood. High dose intravenous glucose tolerance test and serum. Pathogenetic mechanisms of impaired glucose tolerance and. The intravenous glucose tolerance test ivgtt was performed by infusion of 40% glucose solution at 0.
Background the unmodified frequently sampled intravenous glucose tolerance test fsigt has not previously been used to assess insulin glucose kinetics in patients with insulinoma. Benedicts macromethod 6 was used for blood sugar analyses. The effects of metformin on body mass index and glucose. Mathematical modelling of the intravenous glucose tolerance test article pdf available in journal of mathematical biology 402. Accordingly, the intravenous glucose tolerance test would convey greater information.
Results of standard threehour oral glucose tolerance tests ogtt and intravenous glucose tolerance tests ivgtt, performed on the same subjects, were compared in an attempt to determine their value. Research design and methods we performed a frequently sampled intravenous glucose tolerance test fsigt with minimal model analysis and a meal tolerance test mtt in 20. Blood pyruvate and lactate levels during oral and intravenous. Tis the time required in minutes for blood glucose concentration to return to the initial value, see text.
The test is usually used to test for diabetes, insulin resistance, impaired beta cell function, and sometimes reactive hypoglycemia and acromegaly, or rarer disorders of carbohydrate metabolism. The rise and fall of the blood glucose concen tration following oral or intravenous administra tion of glucose the glucose tolerance curve has long been. Paw data of intravenous glucos tolerance tests on sixty normal subjects. Pdf mathematical modelling of the intravenous glucose. Modeling studies of the insulinglucose relationship have mainly utilized parametric models, most notably the minimal model mm of glucose disappearance. A total of 83 such tests were carried out on 81 subjects. A number of reports have appeared in the literature describing abnormal glucose tolerance in various mental disorders as measured by reduction in tolerance for ingested sugar.
Results of standard threehour oral glucose tolerance tests ogtt and intravenous glucose tolerance tests ivgtt, performed on the same subjects, were compared in an attempt to determine their value in the diagnosis of borderline diabetes. Evaluation of a simplified intravenous glucose tolerance. An oral glucose tolerance test ogtt was performed on each subject. Thorndike memorial laboratory, second and fourth medical services harvard, boston city hospital, boston, mass. The intravenous glucose tolerance test iv gtt was performed by infusion of 40% glucose solu tion at 0. The intravenous glucose tolerance test in normal vaginally delivered neonates, 3 to 6 hours old, is abnormal by adult standards.
The present study compared the intravenous glucose tolerance test ivgtt and the glucose postprandial response gppr test for the evaluation of glucose metabolism in obese dogs. Diagnostic capabilities of the intravenous glucose tolerance test. Glucose tolerance test ivgtt 3,4, graded glucose infusion test ggi57, hyperglycemic clamp8,9, etc. Intravenous glucose tolerance test an overview sciencedirect. The intravenous glucose tolerance test ivgtt in animals must also be standardized for best results kaneko et al. A simple intravenous glucose tolerance test for assessment of. Although the factors that contribute to the development of type 2. The aim of the study was to find a simple intravenous glucose tolerance test ivgtt that can be used to estimate insulin sensitivity. Mean fasting blood pyruvate levels were similar in nondiabetic, maturityonset diabetic and insulinrequiring diabetic subjects of similar degree of obesity. Improvement of the intravenous glucose tolerance test nature. Application of the intravenous glucose tolerance test and.
Response to intravenous glucosetolerance test and risk of. Valdes 1 departments of obstetrics and gynecology and medicine, baylor college of medicine houston, texas 77054. Application of the intravenous and oral glucose tolerance. Several attempts at building a satisfactory model of the glucose insulin system are recorded in the literature. An intravenous glucose tolerance test automatically eliminates variations due to gastrointestinal factors. Intravenous glucose tolerance tests were performed on 232 randomly selected, pregnant subjects and 149 of the same women post partum. There is an initial slow rate of glucose disappearance from the blood. Bonsnes with the technical assistance of beatrice barad from the department of. The minimal model, which is the model currently mostly used in. This article presents results from the comparative.
Eighteen to 20 hours prior to the glucose tolerance test, cats were anesthe tized by intravenous injection of thiamylal sodium up to 17 mgkg body weight. Pdf intravenous glucose tolerance test and glucose kinetic. The high dose intravenous glucose tolerance test and concurrent immunoreactive serum insulin and glucagon levels were measured and the results related to the presence or absence of pancreatic insular amyloid in 16 cats, seven of which were known to be diabetic. Intravenous glucose tolerance testderived insulin sensitivity changes during the menstrual cycle cecilia t.
Intravenous glucose tolerance test by plotting the data log increment against time and then applying the formula k loge2 t where t is the time in minutes required for the blood glucose increment value at anypoint to be halved. In order to evaluate the diagnostic reliability of the oral glucose tolerance test ogtt and the intravenous glucose tolerance test ivgtt, the results of these two teats have beencompared both to each other as well as to a third test of carbohydrate tolerance termed the pancreatic suppression test pst, in fortyfive subjects. When results of the ivgtt and ogtt are compared, there is a 40. The iv glucose tolerance blood test helps determine glucose levels in blood, after intravenous administration of a 50% solution of glucose. It is used to diagnose diabetes, cancers, and metabolic disorders. Evaluation of a simplified intravenous glucose tolerance test.
The extent of variation of the test was first determined in normal individuals. Glucose tolerance means ability of the body to utilize glucose in the circulation. Intravenous glucose tolerance test derived insulin sensitivity changes during the menstrual cycle cecilia t. A total of ten owned obese dogs body condition score bcs of 9. Oral versus intravenous glucose tolerance tests during pregnancy.
Accordingly, the intravenous glucose tolerance test would convey greater information if. Nov 07, 2018 the iv glucose tolerance blood test helps determine glucose levels in blood, after intravenous administration of a 50% solution of glucose. Impaired glucose tolerance can also be detected with the intravenous glucosetolerance test ivgtt, where an artificial increase in plasma glucose induces insulin secretion from pancreatic. A cohort of 945 healthy men, aged 4059 years in 197275, was followed for 40 years. In 20 healthy volunteers aged between 18 and 51 years mean, 28 comparisons were made between kinetic parameters derived from a 12sample, 75min ivgtt and the mbw glucose uptake obtained during a hyperinsulinemic euglycemic glucose clamp. Pdf a simple intravenous glucose tolerance test for assessment of. Colesevelam improves oral but not intravenous glucose. Effects of anesthesia on hyperglycemic and insulinotropic. The glucose tolerance test gtt is the most sensitive test for detecting borderline diabetes mellitus. Intravenous glucose tolerance technique ofthe test various doses andmethods ofadministration have been employed, but the following technique has beenfoundmostgenerally satisfactory. To analyze the data from these tests, new criteria. This index, which will be referred to as the increment index, measures glucose tolerance as the fall of.
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